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Green tea extracts can act as neurotoxicity inhibitors

The study conducted by Canada's McMaster University revealed the potential mechanism of green tea for the brain. The antioxidant and detoxifying properties of green tea extracts help combat catastrophic diseases such as Alzheimer's disease. However, scientists have not fully understood their role at the molecular level and how they can be used to find better treatments. Preclinical evidence indicates that the main component of green tea polyphenols is called EGCG (epigallocatechin-3-gallate) and can interfere with the assembly of toxic oligomers in the brain of people with Alzheimer's disease, at the molecular level. The early steps in the association are one of the important factors that lead to a decline in the cognitive abilities of patients.

New method of nuclear magnetic resonance decryption molecular mechanism

Professor Giuseppe Melacini explained that they believe that EGCG encapsulates toxic oligomers and prevents them from developing and interacting with healthy cells. However, the molecular mechanism of EGCG induction is not completely understood.

Combining 15N and 1H Dark State Exchange Saturation Transfer (DEST), a new method of nuclear magnetic resonance, and the use of fluorescent chemical shift projection NMR, dynamic light scattering, and electron microscopy methods to investigate the oligomerization of beta-amyloid by EGCG The impact of things. They found that after combining with EGCG, the structure of Aβ (1–40) has changed a lot. These obvious structural changes provide the basis for understanding the molecular mechanism of why EGCG is a neurotoxic inhibitor.

The researchers said that this discovery is the result of the development of nuclear magnetic resonance (NMR) methods, and also reflects the effectiveness of DEST-based new methods of nuclear magnetic resonance in the discovery of low molecular weight amyloid inhibitors. This discovery was published on the cover of the top journal of the discipline of chemistry and may lead to new treatments and further drug discovery.

The actual implementation still has problems to be solved

As soon as symptoms appear, Alzheimer's disease cannot be cured, so it is best to be able to intervene early. This may mean that green tea extracts or derivatives thereof can be used 15 to 25 years before the onset of the disease, when there are no symptoms.

Next, the researchers hope to solve some of the problems that have caused difficulties in practical implementation, such as how to modify EGCG and similar molecules so that they can be effectively used as food additives. EGCG is unstable at room temperature and it is known that it is difficult to enter the human body, especially the brain.

Professor Melacini stated that "food additives may be a key or complementary treatment. In addition to exercise and a healthy lifestyle, the value of using food additives when people are still young is very important for increasing healthy aging opportunities."

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